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Dr. Gustavo Pradilla

Dr. Gustavo Pradilla, MD, FAANS

Chief of Neurosurgery

Dr. Gustavo Pradilla is an associate professor of neurosurgery at the Emory University School of Medicine, he serves as chief of the neurosurgery service at Grady Memorial Hospital and is the co-director of the Grady Skull Base Surgery Center. Dr. Pradilla completed his training in neurosurgery at the Johns Hopkins Hospital in 2012 and his fellowship training in cerebrovascular and skull base surgery at the University of Miami Miller School of Medicine in 2013. In addition he received postdoctoral research training in cerebrovascular research and experimental neuro-oncology at the Johns Hopkins University School of Medicine prior to his residency training. Dr. Pradilla is the director of the cerebrovascular research laboratory for the Department of Neurosurgery and a member of the Emory Brain Research Laboratory. He specializes in the surgical treatment of cerebrovascular disorders including aneurysms, arteriovenous malformations, and carotid artery stenosis, as well as in open and endoscopic surgery for brain and skull base tumors. His basic and clinical cerebrovascular research focuses on subarachnoid hemorrhage, intracerebral hemorrhage, and intracranial aneurysm formation, and his research in skull base surgery focuses on microsurgical anatomy and technique development in skull base surgery.

Specialties

  • Neurosurgery

Board Certifications

  • ABMS Neurological Surgery

Fellowships

  • Miller School of Medicine

Affiliations

  • Emory

Education & Training

  • Medical School: Pontificia Universidad
  • Internship: John Hopkins Hospital
  • Residency: Johns Hopkins Hospital

Honors & Awards

2004 Galbraith Award of the Joint AANS/CNS Cerebrovascular Section

2004 Agustus McCravey Award of the Southern Neurosurgical Society

2004 Harvey Cushing Hunterian Research Award for highest achievement in Neurosurgical Research

2008 Sherman Travel Fellowship Award 2009 Order of Merit of the City of Bucaramanga, Colombia. Awarded by the Mayor of the City of Bucaramanga, Colombia to its distinguished citizens

2009 Academic Recognition of the Universidad Industrial de Santander (UIS) in Bucaramanga, Colombia awarded by the UIS President for contributing to the advancement of the neurosciences

2011 Walter E. Dandy Award for Excellence in Neurosurgery for highest achievement in Clinical Neurosurgical Research

2011 Fellowship award for the Clinical Trial Methods Course (CTMC) in Neurology awarded by the National Institute of Neurological Disorders and Stroke (NINDS) (August 15-21, 2011,Vail, CO)

2014 “One in one-hundred” Outstanding Post-Doctoral Fellow Mentor award, Emory University School of Medicine

2014 “Kristen’s Legacy of Love Chair of Research” from the Brain Aneurysm Foundation

2017 “Doctors Day” Featured Faculty Member, Emory School of Medicine Recognitions Committee

Publications

Frazier JL, Wang PP, Case D, Tyler BM, Pradilla G, Weingart JD, Brem H. Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. J Neurooncol. 2003; 64:203-209. PMID: 14558595

Restrepo L, Pradilla G, Llinas R, Beauchamp NJ. Perfusion- and diffusion-weighted MR imaging-guided therapy of vertebral artery dissection: Intra-arterial thrombolysis through an occipital vertebral anastomosis. AJNR Am J Neuroradiol. 2003; 24:1823-1826. PMID: 14561610

Pradilla G, Wang PP, Legnani FG, Ogata L, Dietsch GN, Tamargo RJ. Anti-CD11/CD18 monoclonal antibody therapy prevents vasospasm after subarachnoid hemorrhage in rabbits. J Neurosurg. 2004 July; 101(1):88-91. PMID: 15255256

Pradilla G, Wang PP, Legnani FG, Frazier JL, Tamargo RJ. Pharmacokinetics of controlled release polymers in the subarachnoid space after subarachnoid hemorrhage in rabbits. J Neurosurg. 2004 July; 101(1):99-103. PMID: 15255258

Frazier JL, Pradilla G, Wang PP, Tamargo RJ. Inhibition of experimental cerebral vasospasm by intracranial delivery of ibuprofen from a controlled-release polymer in a rabbit subarachnoid hemorrhage model. J Neurosurg. 2004 July; 101 (1): 93-98. PMID: 15255257

Pradilla, G., Thai, Q.A., Legnani, F. G., Hsu, W., Kretzer, R.M., Wang, P. P., Tamargo, R. J. Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits. Neurosurgery 2004 December; 55 (6):1393-99. PMID: 15574221

Mantha, A., Legnani, F.G., Bagley, C.A., Gallia, G., Garonzik, I., Pradilla, G., Amundson, E., Tyler, B.M., Brem, H., Gokaslan, Z. A new model of spinal metastasis in rats. J Neurosurg Spine 2005 March; 2 (3): 303-307. PMID: 15796355 Cover Article.

Brastianos, P., Pradilla, G., McCarthy, E., Gokaslan, Z.L. Solitary osteochondroma of the T12 vertebra: Case Report and Review of the Literature. Neurosurgery, 2005 June; 56 (6):1379. PMID: 15918958

Pradilla, G., Thai, Q.A., Legnani, F.G., Clatterbuck, R.E., Gailloud, P., Murphy, K.P.J., Tamargo, R.J. Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. Neurosurgery, 2005 July; 57 (1 Suppl):184-90. PMID: 15987587

Thai, Q.A., Raza, S.M., Pradilla, G., Tamargo, R.J. Aneurysmal rupture without subarachnoid hemorrhage, case series. Neurosurgery, 2005, August; 57 (2):225-9. PMID: 16094149

Amundson, E., Pradilla, G., Brastianos, P., McCarthy, E., Gokaslan, Z.L. A novel intravertebral tumor model in rabbits. Neurosurgery, 2005, August; 57 (2): 341-6. PMID: 16094165

Mavinkurve, G., Pradilla, G., Legnani, F.G., Bagley, C.A., Brem, H., Jallo, G. A novel intramedullary spinal cord tumor model in rabbits: functional, radiological, and histopathological characterization. J Neurosurg Spine, 2005 August; 3 (2): 142-8. PMID: 16370303

Pradilla, G., Legnani, F. G., Petrangolini, G., Francescato, P., Chillemi, F., Tyler, B. M., Brem, H., Olivi, A., DiMeco, F. Local delivery of a novel endostatin fragment for the treatment of experimental gliomas. Neurosurgery, 2005 November; 57 (5):1032-40. PMID: 16284573

Recinos, P.F., Pradilla, G., Thai, Q.A., Crompton, P., Rigamonti, D. Management of spinal epidural abscesses. Oper Techn Neurosurg (Editor: Spetzler, R.F.), 2005 September; 7: 188-192.

Pradilla, G., Wang, P.P., Gabikian, P., Li, K.W., Magee, C., Brem, H., Walter, K.A. Local intracerebral administration of paclitaxel with the Paclimer® delivery system: toxicity study in a canine model. J Neurooncol. 2006 Jan;76(2):131-8. PMID: 16284923

McGirt, M.J., Woodworth, G., Pradilla, G., Legnani, F.G., Warner, D., Tamargo, R.J., Clatterbuck, R.E., Lynch, J.R, Laskowitz, D.T. Simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. Clinical Neurosurgery, 2004 October; 52 (49): 212-213. PMID: 16626096

Legnani, F.G., Pradilla, G., Thai, Q.A., Fiorindi, A., Recinos, P.F., Tyler, B.M., Gaini, S.M., DiMeco, F., Brem, H., Olivi, A. Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. J Neuro-Oncol., 2006 May; 77 (3): 225-32. PMID: 16609837

McGirt, M.J., Pradilla, G., Legnani, F.G., Thai, Q.A., Recinos, P.F., Tamargo, R.J., Clatterbuck, R.E. Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm. Neurosurgery, 2006 May; 58 (5):945-51; discussion 945-51. PMID: 16639331

Tierney, T., Pradilla, G., Wang, P.P., Clatterbuck, R., Tamargo, R.J. Intracranial Delivery of the Nitric Oxide Donor DETA/NO from a Controlled-Release Polymer: Toxicity in Cynomolgus Monkeys. Neurosurgery 2006 May; 58(5):952-60; discussion 952-60. PMID: 16639332

Caplan, J., Pradilla, G., Hdeib, A., Tyler, B.M., Legnani, F.G., Bagley C.A., Brem, H., Jallo, G. A novel model of intramedullary spinal cord tumors in rats: functional progression and histopathological characterization. Neurosurgery. 2006 Jul; 59(1):193- 200; discussion 193-200. PMID: 16823316

Thai, Q.A., Pradilla, G., Legnani, F.G., Kretzer, R.M., Hsu, W., Tamargo, R.J. Lysis of intracerebral hematoma with stereotactically implanted tissue plasminogen activator polymers in a rabbit model. J Neurosurgery, 2006, Sept; 105 (3): 424-429. PMID: 16961138

Recinos, P.F., Pradilla, G, Thai, Q.A., Perez, M., Legnani, F.G., Hdeib, A., Clatterbuck, R.E., Tamargo, R.J. Lipopolysaccharide-induced cerebral vasospasm is comparable to post-hemorrhagic vasospasm in rabbits. Surgical Neurology, 2006 Nov; 66 (5): 463-9; discussion 469. PMID: 17084186

Brem, S., Tyler, B.M., Li, K., Pradilla, G., Legnani, F.G., Caplan, J., Brem, H. Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model. Cancer Chemother Pharm, 2007 Oct;60(5):643-50. Epub 2007 Jan 26. PMID: 17256133

Pradilla, G., Jallo, G. Arachnoid cysts: case series and review of the literature. Neurosurg focus, 2007 Feb; 22 (2) E7. PMID: 17608350

Chaichana, K. Capilla-Gonzalez, V., Gonzalez-Perez, O., Pradilla, G., Han, J., Olivi, A., Brem, H., Garcia-Verdugo, J.M., Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. J Neurosc Meth. 164 (2007) 261–270. PMID: 17580092

Raza, S., Thai, Q.A., Pradilla, G., Tamargo, R.J. Titanium cranioplasty prevents cosmetic deformities after pterional craniotomies. Neurosurgery, 2008 Mar;62(3 Suppl 1):262-4; discussion 264-5. PMID: 18424995

Raza, S.M., Thai, Q.A., Jabbour, S., Pradilla, G., Kleinberg, L.R., Wharam, M., Rigamonti, D. Repeat stereotactic radiosurgery for high grade and large intracranial arteriovenous malformations. Surg Neurol. 2007 Jul;68(1):24-34; discussion 34. PMID:17586215

Hsu, W., Pradilla, G., Constantini, S., Jallo, G.I. Surgical considerations of spinal ependymomas in the pediatric population. Childs Nerv Syst. 2009 Oct;25(10):1253-9. Epub 2009 Apr 10. PMID: 19360418

Pradilla, G., Rigamonti, D. Epidural abscesses in Africa - Authors' reply. Lancet Neurol. 2009 Oct;8(10):879-80.

Pendleton, C., Zaidi, H., Pradilla, G., Cohen-Gadol, A., Quinones- Hinojosa, A., Harvey Cushing's attempt at the first human pituitary transplantation. Nature Reviews Endocrinology, 2010 January; 6(1):48-52. PMID: 20010970

Jansen, T., Tyler, B., Mankowski, J.L., Renard, V., Pradilla, G., Legnani, F., Laterra, J., Olivi, A. FasL gene knock-down therapy enhances the anti-glioma immune response. Neuro-Oncology, 2010 May; 12(5): 482-9. PMID: 20406899

Tyler, B.M., Fowers, K.D., Li, K., Recinos, V.R., Caplan, J.M., Hdeib, A., Grossman, R., Basaldella, L., Bekelis, K., Pradilla, G., Legnani, F., Brem, H. A thermal gel depot (OncoGel) for local delivery of Paclitaxel to treat experimental brain tumors. J Neurosurgery, 2010 Aug; 113(2): 210-7. PMID: 20001591

Chaichana, K., Pradilla, G., Gokaslan, Z., Bydon, A. The Clinical Significance of Pneumorachis: A Case Report and Review of the Literature. J Trauma, 2010, March, 68(3):736-744. PMID: 20220428

Lazaridis, C., Pradilla, G., Nyquist, P.A., Tamargo, R.J. Intra-aortic balloon pump counterpulsation in the setting of subarachnoid hemorrhage, cerebral vasospasm, and neurogenic stress cardiomyopathy. Neurocrit care, 2010 Aug; 13(1): 101-8. PMID: 20383610

Hsu, W., Pradilla, G., Garonzik, I.M., Conway, J.E. Pretruncal non-aneurysmal subarachnoid hemorrhage causing basilar artery vasospasm. Neurocritical Care, 2010 Oct; 13(2): 256-60. PMID: 20422468

Germanwala, A.V., Thai, Q.A., Pradilla, G., Tamargo, R.J. Simple technique for intraoperative localization of small vascular lesions. Neurosurgery, 2010, Sep; 67(3): 818-22. PMID: 20657315

Pradilla, G., Nagahama, Y., Spivak, A., Bydon, A., Rigamonti, D. Spinal Epidural Abscess: Current Diagnosis and Management. Curr Inf Dis Rep, 2010 Nov;12(6):484- 91. PMID: 21308559

Alvernia, J., Pradilla, G., Mertens, P., Lanzino, G., Tamargo, R.J. Latex injections of cadaver heads: technical note. Neurosurgery, 2010 Dec; 67 Operative Neurosurgery, 2:ons362-ons367. PMID: 21099559

Zaidi, H., Pendleton, C., Pradilla, G., Cohen-Gadol, A. Quinones-Hinojosa, A. Harvey Cushing’s innovative attempt at xenotransplanting a rabbit spinal cord in a patient after resection of peripheral nerve tumor in 1902. Neurosurgery, 2011 Mar;68(3):773-80. PMID: 21311303

Pradilla, G., Garzon-Muvdi, T., Ruzevick, J.J., Bender, M., Edwards, L., Momin, E.N., Thompson, R.C., Tamargo, R.J. Systemic L-citrulline administration prevents cerebral vasospasm in haptoglobin 2-2 transgenic mice after SAH. Neurosurgery, 2012 Mar;70(3):747-56; discussion 756-7. PMID: 21915076

Dasenbrock, H.H., Pradilla, G., Gokaslan, Z.L., Bydon, A. The impact of weekend hospital admission on the timing of intervention and outcomes after surgery for spinal metastases. Neurosurgery, 2012 Mar;70(3):586-93. PMID: 21869727

Bender, M., Pradilla, G., James, C., Raza, S., Lim, M., Carson, B.S. Surgical treatment of pediatric trigeminal neuralgia, case series and review of the literature. Child Nerv Sys, 2011 Dec;27(12):2123-9. Epub 2011 Oct 1. PMID: 21965150

Coon, A., Paul, A.R., Colby, G.P., Lin, L.M., Pradilla, G., Huang, J., Tamargo, R.J. Comparison of tertiary center aneurysm location frequencies in 400 consecutive cases: Decreasing incidence of posterior communicating artery region aneurysms. Surg Neurol Int. 2011;2:152. Epub 2011 Oct 29. PMID: 22140637

Tyler, B.M., Hdeib A., Caplan, J., Legnani, F.G., Fowers, K.D., Brem, H., Jallo, G., Pradilla G. Intra-tumoral administration of the paclitaxel delivery system OncoGel® delays the onset of paresis in rats with intramedullary spinal cord gliosarcoma. J Neurosurg Spine. 2012 Jan;16(1):93-101. PMID: 22208429

Wicks, R.T., Pradilla, G., Raza, S.M., Hadelsberg, U., Huang, J., Tamargo, R.J. Impact of Changes in Intraoperative Somato-Sensory Evoked Potentials (SSEPs) on Stroke Rates after Clipping of Intracranial Aneurysms. Neurosurgery, 2012 May;70(5):1114-24; discussion 1124. PMID: 22067420

Bender, M.T., Pradilla, G., Batra, S., See, A.P., Bhutiani, N., James, C., Carson, B.S., Lim, M. Effectiveness of Repeat Glycerol Rhizotomy in Treating Recurrent Trigeminal Neuralgia. Neurosurgery, 2012 May;70(5):1125-33; discussion 1133-4. PMID: 22067421

Pradilla, G., Coon, A., Huang, J., Tamargo, R.J. Surgical treatment of cranial arteriovenous malformations and dural arteriovenous fistulas. Neurosurg Clin N Am. 2012 Jan;23(1):105-22. PMID: 22107862

Hsu, W., Siu, I., Pradilla, G., Richman, J., Flerage, T., Gokaslan, Z., Jallo, G., Gallia, G. Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres. J Neurosurg Spine. 2012 Mar;16(3):315-9. Epub 2011 Dec 23. PMID: 22195609

Amin, A.G., Ng, J., Hsu, W., Pradilla, G., Raza, S., Quinones-Hinojosa, A., Lim, M. Postoperative anticoagulation management in patients with mechanical heart valves and subdural hematomas. Neurocrit care, 2013 Aug;19(1):90-4. PMID: 22528281

Bender, M., Pradilla, G., Batra, S., See, A.P., James, C., Carson, B.S., Pardo-Villamizar, C., Lim, M. Glycerol Rhizotomy and Radiofrequency Thermocoagulation for Trigeminal Neuralgia in Multiple Sclerosis. J Neuros 2013 Feb;118(2):329-36. PMID: 23121430

Ruzevick, J., Jackson, C., Pradilla, G., Garzon-Muvdi, T., Tamargo, R.J. Aneurysm formation in pro-inflammatory, transgenic haptoglobin 2-2 mice. Neurosurgery, 2013 Jan;72(1):70-6; discussion 76. PMID: 23096414

Pradilla, G., Wicks, R.T., Hadelsberg, U., Gailloud, P., Coon, A.L., Huang, J., Tamargo, R.J. Accuracy of computed tomography angiography in the diagnosis of intracranial aneurysms. World Neuros. 2013 Dec;80(6):845-52. PMID: 23220123

Zeng, J., See, A.P., Phallen, J., Belcaid, Z., Durham, N., Meyer, C., Harris, T., Yu, H., Albesiano, E., Pradilla, G., Ford, E., Wong, J., Hammers, H., Tyler, B., Brem, H., Tran, P.T., Pardoll, D., Drake, C.G., Lim, M. Anti-PD-1 blockade and stereotactic radiation produces long term survivors in mice with intracranial gliomas. Int J Radiation Oncol Biol Phys, 2013, 2013 Jun 1;86(2):343-9 PMID: 23462419

Garzon-Muvdi, T., Pradilla, G., Ruzevick, J.J., Bender, M., Edwards, L., Grossman, R., Zhao M., Rudek, M.A., Riggins, G., Tamargo, R.J. A glutamate receptor antagonist, S-4- carboxyphenylglycine (S-4-CPG), inhibits vasospasm after subarachnoid hemorrhage in Haptoglobin 2-2 mice. Neurosurgery, 2013 Oct;73(4):719-28; discussion 729. PMID: 23842553

Pradilla, G., Heros, R.C. Importance of the venous outflow pattern in predicting hyperemic complications after treatment of cerebral AVMs. World Neurosurg. 2014 Jul- Aug;82(1-2):e59-60. PMID: 24035991

Wicks, R.T., Huang, Y., Zhang, K., Zhao, M., Tyler, B.A., Suk, I., Hwang, L., Ruzevick, J., Jallo, G., Brem, H., Pradilla, G., Kang, J.U. Extravascular Optical Coherence Tomography: Evaluation of Carotid Atherosclerosis and Pravastatin Therapy. Stroke, 2014 Apr;45(4):1123-30. PMID: 24627118

Tyler, B., DiMeco, F., Grossman, R., Pradilla, G. Current and future novel treatments for glioblastoma multiforme. Biomed Res Int. 2014; 2014:432195. Epub 2014 Dec 22. PMID: 25587536

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT, Merck LH, Janis LS, Barsan WG; NETT Investigators (Pradilla, G). Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014 Dec 25;371(26):2457-66. Epub 2014 Dec 10. PMID: 25493974

Ruzevick, J., Raza, S.M., Recinos, P.F., Chaichana, K., Pradilla, G., Kim, J.E., Olivi, A., Weingart, J.D., Evans, J., Quinones-Hinojosa, A., Lim, M. Technical Note: orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies. Clin Neurol Neurosurg. 2015 Apr 13;134:24-27. PMID: 25935127

Roy, A.K., Miller, B.A., Holland, C.M., Fountain, A.J., Pradilla, G., Ahmad, F.U. Magnetic Resonance Imaging of Traumatic Injury to the Cranio-vertebral Junction: A Case-Based Review. Neurosurg Focus. 2015 Apr;38(4):E3. PMID: 25828497

McCracken, D.J., Pradilla, G., Barrow, D.L. Intracranial blister aneurysms: clip reconstruction techniques. Neurosurgical Focus, 2015, in press. Jul;39 Video Suppl 1:V20. PMID: 26132619

Pradilla, G., Barrow, D.L. Commentary for “Normal perfusion pressure breakthrough theory: A reappraisal after 35 years”. World Neurosurgery, 2015, in press

McCracken, D.J., Lovasik, B.P., McCracken, C.E., Caplan, J.M., Turan, N., Nogueira, R., Cawley, C.M., Dion, J.E., Tamargo, R.J., Barrow, D.L., Pradilla, G. Resolution of Oculomotor Nerve Palsy Secondary to Posterior Communicating Artery Aneurysms: Comparison Between Clipping and Coiling. Neurosurgery 2015 Dec;77(6):931-9; discussion 939. PMID: 26287555

Murthy, S.B., Caplan, J., Levy, A.P., Pradilla, G., Moradiya, Y., Schneider, E.B., Shalom, H., Ziai, W.C., Tamargo, R.J., Nyquist, P.A. Haptoglobin 2-2 genotype is associated with cerebral salt wasting syndrome in aneurysmal subarachnoid Hemorrhage. Neurosurgery 2016 Jan;78(1):71-6. PubMed PMID: 26348010

Akinduro, O., Miller, B.A., Haussen, D., Pradilla, G., Ahmad, F. Complications of intraoperative epidural steroid use in lumbar discectomy: a systematic review and meta- analysis. Neurosurg Focus. 2015 Oct;39(4):E12. PubMed PMID: 26424336.

Turan, N., Baum, G., Holland, C., Ahmad, F., Henriquez, O., Pradilla, G. Upper nasopharyngeal corridor for transnasal endoscopic drainage of petroclival cholesterol granulomas, alternative access in conchal sphenoid patients. J Neurol Surg Rep 2016 Mar;77(1):e017-22. doi: 10.1055/s-0035-1567865. Epub 2015 Nov 16. PubMed PMID: 26929897

Salehani, A., Baum, G., Pradilla, G., Ahmad, F. Double Cervical Fracture-subluxation at Adjacent Levels. Spine J. 2015 Oct 12. Epub ahead of print. PubMed PMID: 26471707.

Elyas, J., Kulwin, C., Glyn, R., Rovin, R., Young, R., Alzate, J., Pradilla, G., Shah, M., Kassam, A., Bailes, J. Minimally-invasive trans-sulcal resection of Intra-ventricular and Peri-ventricular lesions through a tubular retractor system: Multi-centric experience and results. World Neurosurg. 2016 Jan 21. [Epub ahead of print] PubMed PMID: 26805678.

Miller, B.A., Roy, A.K., Boucher, A.B., Pradilla, G., Ahmad, F.U. Subacute Posttraumatic Ascending Myelopathy After an Incomplete Spinal Cord Injury from a Gunshot Wound to the Spine: Case Report and Review of the Literature. World Neurosurg. 2015 Dec17. [Epub ahead of print] PubMed PMID: 26704212.

Baum, G.R., Turan, N., Buonano, F.S., Pradilla, G., Nogueira, R.G. Intracranial dural arteriovenous fistula as a cause for symptomatic superficial siderosis: A report of two cases and review of the literature. Surg Neurol Int. 2016 Apr 1;7(Suppl 9):S223-7. 2016. PubMed PMID: 27127712.

Chaudhry, N., Ambekar, S., Elhammady, M.S., Riley, J.P., Nogueira, R., Pradilla, G., Ahmad, F. Combined Use of Intraoperative ICG and Dynamic Angiography in Rotational Vertebral Artery Occlusion. J Clin Neurosci. 2016 Mar 31 2016.02.007. [Epub ahead of print] PubMed PMID: 27041076.

Howard, B.M., Rindler, R.S., Holland, C.M., Pradilla, G., Ahmad, F.U. Management and Outcomes of Isolated Tentorial and Parafalcine ‘Smear’ Subdural Hematomas at a Level- 1 Trauma Center: Is high acuity care really necessary? J Neurotrauma. 2016, Mar 29. [Epub ahead of print] PubMed PMID: 27025978.

Baum, G.R., Turan, N., Buonanno, F.S., Pradilla, G., Nogueira, R.G. Intracranial dural arteriovenous fistula as the cause for symptomatic superficial siderosis – A report of two cases treated successfully with endovascular therapy. Surg Neurol Int. 2016 Apr 1;7(Suppl 9):S223-7. doi: 10.4103/2152-7806.179577. eCollection 2016. PMID: 27127712

Halani, S.H., Baum, G.R., Riley, J.P., Pradilla, G., Refai, D., Rodts, G.E. Jr, Ahmad, F.U. Esophageal perforation after anterior cervical spine surgery: a systematic review of the literature. J Neurosurg Spine. 2016 Apr 15:1-7. [Epub ahead of print] PubMed PMID: 27081708.

Labib., M., Shah, M., Kassam, A., Young, R., Zucker, L., Maioriello, A., Britz, G., Agbi, C., Day, J., Gallia, G., Kerr, R., Pradilla, G., Rovin, R., Kulwin,, C., Bailes, J. The Safety and Efficacy of Image- Guided BrainPath-Mediated Trans-Sulcal Hematoma Evacuation: A Multicenter Study. Neurosurgery. 2016 Jun 17. [Epub ahead of print] PubMed PMID: 27322807.

Lovasik, B.P., McCracken, D.J., McCracken, C.E., McDougal, M.E., Frerich, J.M. Samuels, O.B., Pradilla, G. The Effect of External Ventricular Drain Use in Intracerebral Hemorrhage. World Neurosurg. 2016, July 16. Epub ahead of print. PMID: 27436212

Akinduro, O.O., Baum, G.R., Howard, B.M., Pradilla, G., Grossberg, J.A., Rodts, G.E., Ahmad, F.U. Neurological outcomes following iatrogenic vascular injury during posterior atlanto-axial instrumentation. Clin Neurol Neurosurg. 2016 Aug 30;150:110-116. PMID: 27618782.

Halani, S., Riley, J.P., Pradilla, G., Ahmad, F. How safe is Bubble Soccer? J Clin Neurosci. 2016 Sep 10, Epub ahead of print. PMID: 27624223.

Turan, N., Miller, B., Heider, R., Nadeem, M., Sayeed, I., Stein, D., Pradilla, G. Neurobehavioral testing in subarachnoid hemorrhage: a review of methods and current findings in rodents. J Cereb BFM, 2016 Jan 1:271678X16665623. PMID: 27677672

Malcolm, J.G., Miller, B.A., Grossberg, J., Pradilla, G., Ahmad, F.U. Early urgent cranioplasty for symptomatic pseudomeningocele: report of two cases. J Clin Neurosci. 2016 Aug 11. Epub ahead of print. PMID: 27523587

Boulter, J.H., Lovasik, B.P., Baum, G.R., Frerich, J.M., Allen, J.W., Grossberg, J.A., Pradilla, G., Ahmad, F.U. Implications of Isolated Transverse Process Fractures: Is Spine Service Consultation Necessary? World Neurosurg. 2016 Nov;95:285-291. PMID: 27544337

Malcolm, J.G., Rindler, R.S., Chu, J.K., Grossberg, J.A., Pradilla, G., Ahmad, F.U. Complications following cranioplasty and relationship to timing: A systematic review and meta-analysis. J Clin Neurosci. 2016 Nov;33:39-51. PMID: 27499122

Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, Moy CS, Silbergleit R, Steiner T, Suarez JI, Toyoda K, Wang Y, Yamamoto H, Yoon BW; ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network (Pradilla, G.). Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. N Engl J Med. 2016 Sep 15;375(11):1033-43. PMID: 27276234

Chu, J., Rindler, R., Pradilla, G., Rodts, G., Ahmad, F. Percutaneous Instrumentation Without Arthrodesis for Treatment of Thoracolumbar Flexion-Distraction Injuries: a review of the literature. Neurosurgery. 2017 Feb 1;80(2):171-179. PMID: 28173564

Baum, G.R., Hooten, K.G., Lockney, D.T., Fargen, K.M., Turan, N., Pradilla, G., Murad, G.J., Harbaugh, R.E., Glantz, M.J., and the EVD best practice team. External Ventricular Drain Practice Variations: Results from a Nationwide Survey. J Neurosurg. 2017 Jan 13:1-8. PMID: 28084912

Philipp, L.R., McCracken, D.J., McCracken, C.E., Halani, S.H., Lovasik, J.P., Salehani, A.A., Boulter, J.H., Cawley, C.M., Grossberg, J.A., Barrow, D.L., Pradilla, G. Comparison Between CTA and Digital Subtraction Angiography in the Diagnosis of Ruptured Aneurysms. Neurosurgery. 2017 Feb 14. Epub ahead of print. PMID: 28201559

Mustroph, C.M., Malcolm, J.G., Rindler, R.S., Chu, J.K., Grossberg, J.A., Pradilla, G., Ahmad, F.U. Cranioplasty infection and resorption are associated with presence of a ventriculoperitoneal shunt: A systematic review and meta-analysis. World Neurosurg. 2017 Apr 18. pii: S1878-8750(17)30561-2. PMID: 28434961

Malcolm, J.G., Rindler, R.S., Chu, J.K., Chokshi, F., Grossberg, J.A., Pradilla, G., Ahmad, F.U. Early Cranioplasty is Associated with Greater Neurological Improvement: A Systematic Review and Meta-Analysis. Neurosurgery. 2017 Apr 17. doi: 10.1093/neuros/nyx182. [Epub ahead of print]. PMID: 28419358

Haussen, D.C., Grossberg, J.A., Bouslama, M., Pradilla, G., Belagaje, S., Bianchi, N., Allen, J.W., Frankel, M., Nogueira, R.G. Carotid Web (Intimal Fibromuscular Dysplasia) has high stroke recurrence risk and is amenable to stenting. Stroke. 2017 Nov;48(11):3134-3137. Epub 2017 Oct 10. PMID: 29018133

Turan N., Miller B.A., Huie J.R, Heider R.A, Wang J., Wali B., Yousuf S., Ferguson A.R., Sayeed I., Stein D.G., Pradilla G. Effect of Progesterone on Cerebral Vasospasm and Neurobehavioral Outcomes In A Rodent Model of Subarachnoid Hemorrhage. World Neurosurg. 2017 Oct 30. pii: S1878-8750(17)31846-6. doi:10.1016/j.wneu.2017.10.118. [Epub ahead of print] PMID: 29097330

Agarwal, V., Malcolm, J.G., Pradilla, G., Barrow, D.L. Tractography for optic radiation preservation in transcortical approaches to intracerebral lesions. Cureus. 2017 Sep 28;9(9):e1722. doi: 10.7759/cureus.1722. PMID: 29188166

Zarabi, H., Roy, A., Jha, A., Pradilla, G. Refining surgical corridors with whole brain tractography: A Case Series. Cureus. 2017 Sep 10;9(9):e1672. doi: 10.7759/cureus.1672. PubMed PMID: 29152429

McCracken, D.J., Lovasik, B.P., McCracken, C.E., Frerich, J.M., McDougal, M.E., Ratcliff, J.J., Barrow, D.L., Pradilla, G. The Intracerebral Hemorrhage Score: A self-fulfilling prophecy? Neurosurgery, 2018 May 14. doi: 10.1093/neuros/nyy193. [Epub ahead of print] PMID: 29762777

Mason, E.C., Hudgins, P.A., Pradilla, G., Oyesiku, N.M., Solares, C.A. Radiographic Analysis of the Vidian Canal and Its Utility in Petrous Internal Carotid Artery Localization. Oper Neurosurg (Hagerstown). 2018 Feb 21. doi: 10.1093/ons/opx305. [Epub ahead of print] PMID: 29474662

Malcolm, J.G., Mahmooth, Z., Rindler, R.S., Allen, J.W., Grossberg, J.A., Pradilla, G., Ahmad, F.U. Autologous cranioplasty is associated with increased re-operation rate: A systematic review and meta-analysis. World Neurosurg. 2018 May 10. pii: S1878- 8750(18)30954-9. doi:10.1016/j.wneu.2018.05.009. [Epub ahead of print] PMID: 29753896

Bakhsheshian, J., Strickland, B.A., Jackson, C., Chaichana, K.L., Young, R., Pradilla, G., Chen, J.W., Bailes, J., Zada, G. Multicenter Investigation of Channel-Based Subcortical Trans-Sulcal Exoscopic Resection of Metastatic Brain Tumors: A retrospective case- series. Operative Neurosurgery, 2018 Apr 18. doi: 10.1093/ons/opy079. [Epub ahead of print]. PMID: 29912398

Haussen DC, Grossberg JA, Koch S, Malik A, Yavagal D, Gory B, Leesch W, Hassan AE, Derelle AL, Richard S, Barreira C, Pradilla G, Nogueira RG. Multicenter experience with stenting for symptomatic carotid web. Interv Neurol. 2018 Oct;7(6):413-418. doi: 10.1159/000489710. Epub 2018 Jul 11. PMID: 30410519

Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A, Di Meco F. Local delivery of antineoplastic agents using biodegradable polymers for the treatment of malignant brain tumors. Expert Rev Neurotherapeutics. 2003; 3:89-102. PMID: 19810937

Pradilla G, Azzam T, Wang PP, Domb AJ, Brem H. Gene therapy for malignant brain tumors. Expert Rev Neurotherapeutics. 2003; 3:89-105. PMID: 19810968

Raza SM, Pradilla G, Legnani FG, Thai QA, Olivi A, Brem H. Local delivery of antineoplastic agents for the treatment of malignant brain tumors. Expert Opin Mol Ther, 2005, (5) 4: 477-494. PMID: 15934827

Pradilla G, Pradilla-Ardila G, Hsu W, Rigamonti D. Epidural abscesses of the central nervous system. Lancet Neurol 2009; 8: 292–300. PMID: 19233039

Chaichana K, Pradilla G, Huang J, Tamargo RJ. Role of Inflammation (Leukocyte- Endothelial Cell Interactions) in Vasospasm after Subarachnoid Hemorrhage. World Neurosurgery, 2010 Jan;73(1):22-41. Epub 2009 Aug 6. PMID: 20452866

Pradilla G, Chaichana KL, Hoang S, Huang J, Tamargo RJ. Inflammation and cerebral vasospasm after subarachnoid hemorrhage. Neurosurgery Clinics of North America, 2010 Apr; 21(2): 365-79. PMID: 20380976

See AP, Pradilla G, Lim M. Heat-shock protein-peptide complex (HSPPC-96, Oncophage) in the treatment of glioblastoma. Expert Rev Vaccines. 2011 Jun;10(6):721-31. PMID: 21692695

Miller, B.A., Turan, N., Pradilla, G. Inflammation, vasospasm, and brain injury after subarachnoid hemorrhage. Biomed Res Int. 2014;2014:384342. Epub 2014 Jul 3. PMID: 25105123

Turan, N., Heider, R., Zaharieva, D., Ahmad, F., Barrow, D.L., Pradilla, G. Sex Differences in the Formation of Intracranial Aneurysms and Incidence and Outcome of Subarachnoid Hemorrhage: Review of Experimental and Human Studies. Transl Stroke Res. 2016 Feb;7(1):12-9. Epub 2015 Nov 16. PubMed PMID: 26573918

Rindler, R., Miller, B.A., Eshraghi, S., Pradilla, G., Refai, D., Rodts, G., Ahmad, F. Efficacy of transsacral instrumentation for high-grade spondylolisthesis at L5-S1: A systematic review of the literature. World Neurosurg. 2016 May pii: S1878- 8750(16)30304-7. doi: 10.1016/j.wneu.2016.05.030. [Epub ahead of print] PMID: 27216924

Halani, S.H., Chu, J.K., Malcolm, J.G., Rindler, R.S., Allen, J.W., Grossberg, J.A., Pradilla, G., Ahmad, F.U. Effects of Cranioplasty on Cerebral Blood Flow Following Decompressive Craniectomy: A Systematic Review of the Literature. Neurosurgery. 2017 Mar 29. Epub ahead of print. PMID: 28368505

Turan, N., Heider, R.A., Roy, A.K., Miller, B.A., Mullins, M.E., Barrow, D.L., Grossberg, J., Pradilla, G. Current Perspectives in Imaging Modalities for the Assessment of Intracranial Aneurysms: A Comparative Analysis and Review. World Neurosurg. 2018 May;113:280-292. doi: 10.1016/j.wneu.2018.01.054. Epub 2018 Jan 31, PMID: 29360591

Barrow, J.W., Turan, N., Wangmo, P., Roy, A.K., Pradilla, G. The role of inflammation and potential use of sex steroids in intracranial aneurysms and subarachnoid hemorrhage. Surg Neurol Int. 2018; 9: 150. doi: 10.4103/sni.sni_88_18, Epub 2018 Jul 26, PMID: 30105144

Huang Y, Wicks R, Zhang K, Zhao M, Tyler BM, Hwang L, Pradilla G, Kang JU. In-vivo and in-situ detection of atherosclerotic plaques using full-range complex-conjugate-free spectral domain optical coherence tomography in the murine carotid. Proc. SPIE 8565, March 8, 2013. Photonic Therapeutics and Diagnostics IX, 85654P

Haussen DC, Grossberg J, Leesch W, Koch S, Yavagal DR, Barreira C, Pradilla G, Frankel M, Nogueira R. Multicenter experience with stenting for carotid webs. International Stroke Conference 2018, Los Angeles, CA, January 25th, 2018. TP128- 2018 Published in Stroke. 2018;49:ATP128

Pradilla, G., Lesniak, M. S., and Tamargo, R. J. Pediatric intracranial aneurysms. In Current Management in Child Neurology, Third Edition. Ed. B. L. Maria. Hamilton, Ontario: B. C. Decker Inc., chapter 90: 2004. ISBN 1-5509-292-8

Bagley, C., Mavinkurve, G., Pradilla, G., Jallo, G. Advances of Hydrocephalus Management in Spina Bifida Patients. In Trends in Spina Bifida Research. First Edition. Ed. Mario R. Zesta. 2005, Nova Science Publishers, Inc., Hauppauge, NY. ISBN: 9-781- 5945-44-132

Thai, Q.A., Pradilla, G., Rigamonti, D. Capillary Telangiectasias, Cavernous Malformations, andDevelopmentalVenousAnomalies:DifferentExpressionsofthe Same Disease Process? In Cavernous Malformations of the Brain and Spinal Cord. First edition. Ed. G. Lanzino, R. Spetzler, 2008, Thieme Medical Publishers, New York, NY. ISBN 1-588-903-435

Pradilla, G., Thai Q.A., Tamargo R.J. Animal models of subarachnoid hemorrhage. In Acute Stroke: Bench to Bedside. First edition. Ed. A. Bhardwaj, N. Alkayed, J. Kirsch, and R. Traystman. Marcel Decker, Taylor, & Francis Books, Inc., New York, NY, 2006. ISBN: 0-849-3987-0

Thai, Q.A., Pradilla, G., Rigamonti, D. Surgical management of aneurysmal subarachnoid hemorrhage. In Acute Stroke: Bench to Bedside. First edition. Ed. A. Bhardwaj, N. Alkayed, J. Kirsch, and R. Traystman. Marcel Decker, Taylor, & Francis Books, Inc., New York, NY, 2006. ISBN: 0-849-3987-0

Pradilla, G., Thai, Q.A., Gailloud, P., Tamargo, R.J. Central Nervous System vascular malformations. In Current Management in Child Neurology, Fourth Edition. Ed. B. L. Maria. Hamilton, Ontario: B. C. Decker Inc., chapter 90: 2007. ISBN: 1-607-9500-06

Pradilla, G., Sciubba, D.M., Jallo, G. Antibiotic coated-catheters for treatment of pediatric hydrocephalus. In Controversies in pediatric neurosurgery. Ed. G. Jallo, K. Korthbauer, G. Pradilla. Thieme Medical Publishers, New York, NY. 2010. ISBN: 1- 604-0607-43

Chaichana, K. L., G. Pradilla, and R. J. Tamargo. Pediatric intracranial aneurysms. In Current Management in Child Neurology - Fourth Edition. Ed. B. L. Maria. Shelton, Connecticut: B.C. Decker, Inc. / People’s Medical Publishing House, chapter 104: 726- 732, 2009. ISBN: 1-607-9500-06

Pradilla, G., Q.A. Thai, P. Gailloud, and R. J. Tamargo. Central nervous system vascular malformations. In Current Management in Child Neurology - Fourth Edition. Ed. B. L. Maria. Shelton, Connecticut: B.C. Decker, Inc. / People’s Medical Publishing House, chapter 103: 715-725, 2009. ISBN: 1-607-9500-06

Pradilla, G., Solero, C., DiMeco, F. Parasagittal meningiomas. In Meningiomas. Ed. Al- Mefty, O., McDermott, M